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Modeling the Dynamics of Plasmodium vivax Infection and Hypnozoite Reactivation In Vivo

Abstract:

© 2015 Adekunle et al.The dynamics of Plasmodium vivax infection is characterized by reactivation of hypnozoites at varying time intervals. The relative contribution of new P. vivax infection and reactivation of dormant liver stage hypnozoites to initiation of blood stage infection is unclear. In this study, we investigate the contribution of new inoculations of P. vivax sporozoites to primary infection versus reactivation of hypnozoites by modeling the dynamics of P. vivax infection in Thail...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pntd.0003595

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
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Institution:
University of Oxford
Oxford college:
Wadham College
Role:
Author
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/Wellcome Trust More from this funder
Publisher:
PLoS Publisher's website
Journal:
PLoS Neglected Tropical Diseases Journal website
Issue:
3
Publication date:
2015-03-01
Acceptance date:
2015-02-05
DOI:
ISSN:
1935-2735
Pmid:
25780913
Source identifiers:
514969
Language:
English
Keywords:
Pubs id:
pubs:514969
UUID:
uuid:78626775-73e3-4bb5-9d98-fbee0fc0e196
Local pid:
pubs:514969
Deposit date:
2016-08-08

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