Thesis
Targeting PFKFB4 in mitotically vulnerable ovarian cancer cells
- Abstract:
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Taxanes represent some of the most common chemotherapeutic agents for ovarian cancer treatment. However, they are only effective in approximately 40% of patients. As such, novel therapeutic strategies are required to potentiate their effect in ovarian cancer to improve patient outcome and prevent chemotherapy resistance.
A hallmark of many cancers is the constitutive activation of the PI3K/AKT pathway, which drives cell survival and metabolism. In this thesis, I identified a potenti...
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Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Keywords:
- UUID:
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uuid:785caf89-6ba9-4077-8eab-38bbf5ffcc89
- Deposit date:
- 2017-07-03
Related Items
Terms of use
- Copyright holder:
- Taylor, C
- Copyright date:
- 2016
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