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Thesis

Targeting PFKFB4 in mitotically vulnerable ovarian cancer cells

Abstract:

Taxanes represent some of the most common chemotherapeutic agents for ovarian cancer treatment. However, they are only effective in approximately 40% of patients. As such, novel therapeutic strategies are required to potentiate their effect in ovarian cancer to improve patient outcome and prevent chemotherapy resistance.

A hallmark of many cancers is the constitutive activation of the PI3K/AKT pathway, which drives cell survival and metabolism. In this thesis, I identified a potenti...

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Division:
MSD
Department:
Women's and Reproductive Health
Department:
DARS
Role:
Author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Keywords:
UUID:
uuid:785caf89-6ba9-4077-8eab-38bbf5ffcc89
Deposit date:
2017-07-03

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