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The mechanism underlying the positive inotropic effect of angiotensin II in the isolated perfused rabbit heart: a 31P NMR study.

Abstract:

Activation of the Na(+)/H(+) exchanger may play an important role in the development of cardiac hypertrophy. Isolated ventricular myocyte studies have suggested that angiotensin II (AII) has direct positive inotropic effect caused by intracellular alkalinization due to increased Na(+)/H(+) exchange, but whether this occurs in the whole heart is unknown. Consequently, we have used non-invasive 31P NMR spectroscopy to determine whether AII stimulation alters energetics or intracellular pH (pH(i...

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Publication status:
Published

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Authors


Paterson, DJ More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Journal:
The international journal of biochemistry and cell biology
Volume:
35
Issue:
6
Pages:
984-991
Publication date:
2003-06-05
DOI:
EISSN:
1878-5875
ISSN:
1357-2725
URN:
uuid:78560275-a1f3-4d44-a6d8-bfcb34c5ba1c
Source identifiers:
106283
Local pid:
pubs:106283

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