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Sensitive and specific immunodetection of human glandular kallikrein 2 in serum.

Abstract:

BACKGROUND: Human glandular kallikrein 2 (hK2) is expressed in the prostate and is present in serum from men with prostate cancer. Specific detection in serum is difficult mainly because of low concentrations and immunological cross-reactivity with prostate-specific antigen (PSA). Our objectives were to design an assay with improved analytical detection and functional sensitivity and nonsignificant cross-reactivity with PSA, and to characterize different immunoreactive forms of hK2. METHODS: ...

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Role:
Author
Journal:
Clinical chemistry
Volume:
46
Issue:
2
Pages:
198-206
Publication date:
2000-02-05
EISSN:
1530-8561
ISSN:
0009-9147
URN:
uuid:785322e8-12d4-4b59-b04b-c9dd0fd10ef9
Source identifiers:
366055
Local pid:
pubs:366055

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