Journal article
Stem cell modeling of mitochondrial parkinsonism reveals key functions of OPA1
- Abstract:
-
Objective
Defective mitochondrial function due to OPA1 mutations causes primarily optic atrophy and less commonly neurodegenerative syndromes. The pathomechanism by which OPA1 mutations trigger diffuse loss of neurons in some but not all patients is unknown. Here we used a tractable iPSC-based model to capture the biology of OPA1 haploinsufficiency in cases presenting with classic eye disease versus syndromic parkinsonism.
Methods
iPSC were generated from two pati...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Version of record, pdf, 1.2MB)
-
- Publisher copy:
- 10.1002/ana.25221
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
National Institute for Health Research
More from this funder
Oxford Biomedical Research Centre
More from this funder
Oxford Martin School
More from this funder
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Annals of Neurology Journal website
- Publication date:
- 2018-03-31
- Acceptance date:
- 2018-03-23
- DOI:
- EISSN:
-
1531-8249
- ISSN:
-
0364-5134
- Pmid:
-
29604226
- Source identifiers:
-
833983
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:833983
- UUID:
-
uuid:784a9394-0eeb-4e59-bd56-8c307d8f5182
- Local pid:
- pubs:833983
- Deposit date:
- 2018-04-09
Terms of use
- Copyright date:
- 2018
If you are the owner of this record, you can report an update to it here: Report update to this record