Journal article
Quantal Ca2+ release mediated by very few IP3 receptors that rapidly inactivate allows graded responses to IP3
- Abstract:
-
Inositol 1,4,5-trisphosphate receptors (IP3Rs) are intracellular Ca2+ channels that link extracellular stimuli to Ca2+ signals. Ca2+ release from intracellular stores is “quantal”: low IP3 concentrations rapidly release a fraction of the stores. Ca2+ release then slows or terminates without compromising responses to further IP3 additions. The mechanisms are unresolved. Here, we synthesize a high-affinity partial agonist of IP3Rs and use it to demonstrate that quantal responses do not require ...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, 4.1MB, Terms of use)
-
- Publisher copy:
- 10.1016/j.celrep.2021.109932
Authors
Funding
Bibliographic Details
- Publisher:
- Cell Press
- Journal:
- Cell Reports More from this journal
- Volume:
- 37
- Issue:
- 5
- Article number:
- 109932
- Publication date:
- 2021-11-02
- Acceptance date:
- 2021-10-13
- DOI:
- ISSN:
-
2211-1247
Item Description
- Language:
-
English
- Keywords:
- Pubs id:
-
1202840
- Local pid:
-
pubs:1202840
- Deposit date:
-
2021-10-18
Terms of use
- Copyright holder:
- Rossi et al.
- Copyright date:
- 2021
- Rights statement:
- ©2021 The Author(s). This is an open access article distributed under the terms of the Creative Commons CC-BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record