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Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy.

Abstract:

The mechanisms by which gene expression is regulated by oxygen are of considerable interest from basic science and therapeutic perspectives. Using mass spectrometric analyses of Saccharomyces cerevisiae ribosomes, we found that the amino acid residue in closest proximity to the decoding center, Pro-64 of the 40S subunit ribosomal protein Rps23p (RPS23 Pro-62 in humans) undergoes posttranslational hydroxylation. We identify RPS23 hydroxylases as a highly conserved eukaryotic subfamily of Fe(II...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1311750111

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
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Publisher:
National Academy of Sciences
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
111
Issue:
11
Pages:
4019-4024
Publication date:
2014-03-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:781ac34c-a205-48dc-bdf6-1f4c7d56a937
Source identifiers:
449129
Local pid:
pubs:449129

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