- Abstract:
-
The mechanisms by which gene expression is regulated by oxygen are of considerable interest from basic science and therapeutic perspectives. Using mass spectrometric analyses of Saccharomyces cerevisiae ribosomes, we found that the amino acid residue in closest proximity to the decoding center, Pro-64 of the 40S subunit ribosomal protein Rps23p (RPS23 Pro-62 in humans) undergoes posttranslational hydroxylation. We identify RPS23 hydroxylases as a highly conserved eukaryotic subfamily of Fe(II...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1073/pnas.1311750111
-
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- Publisher:
- National Academy of Sciences
- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 111
- Issue:
- 11
- Pages:
- 4019-4024
- Publication date:
- 2014-03-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:781ac34c-a205-48dc-bdf6-1f4c7d56a937
- Source identifiers:
-
449129
- Local pid:
- pubs:449129
- Copyright date:
- 2014
Journal article
Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy.
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