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The generation of nitric oxide and carbon monoxide produces opposite effects on the release of immunoreactive interleukin-1beta from the rat hypothalamus in vitro: evidence for the involvement of different signaling pathways.

Abstract:

Both the cytokine, interleukin-1 (IL-1), and the gaseous neurotransmitters, nitric oxide (NO) and carbon monoxide (CO), have been implicated in the control of neuroendocrine functions, such as the release of CRH and luteotropic hormone-releasing hormone from the hypothalamus. Though increased levels of IL-1 in this brain region are unambiguously associated with enhanced CRH and reduced luteotropic hormone-releasing hormone release, the net effects of the two gases are still unclear, but in vi...

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Publication status:
Published

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Publisher copy:
10.1210/en.139.3.1031

Authors


Mancuso, C More by this author
Tringali, G More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Preziosi, P More by this author
Navarra, P More by this author
Journal:
Endocrinology
Volume:
139
Issue:
3
Pages:
1031-1037
Publication date:
1998-03-05
DOI:
EISSN:
1945-7170
ISSN:
0013-7227
URN:
uuid:78163aa1-1246-4764-bcce-5cbe5751abea
Source identifiers:
138732
Local pid:
pubs:138732

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