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Male and female Plasmodium falciparum mature gametocytes show different responses to antimalarial drugs.

Abstract:

It is the mature gametocytes of Plasmodium that are solely responsible for parasite transmission from the mammalian host to the mosquito. They are therefore a logical target for transmission-blocking antimalarial interventions, which aim to break the cycle of reinfection and reduce the prevalence of malaria cases. Gametocytes, however, are not a homogeneous cell population. They are sexually dimorphic, and both males and females are required for parasite transmission. Using two bioassays, we ...

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Publisher copy:
10.1128/aac.00325-13

Authors


Delves, MJ More by this author
Ruecker, A More by this author
Straschil, U More by this author
Lelièvre, J More by this author
Marques, S More by this author
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Journal:
Antimicrobial agents and chemotherapy
Volume:
57
Issue:
7
Pages:
3268-3274
Publication date:
2013-07-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:780c7f39-5d9c-420b-9778-30b86e2ff54f
Source identifiers:
402110
Local pid:
pubs:402110

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