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Voltage-gated and resting membrane currents recorded from B-cells in intact mouse pancreatic islets.

Abstract:

1. The perforated patch whole-cell configuration of the patch-clamp technique was applied to superficial cells in intact pancreatic islets. Immunostaining in combination with confocal microscopy revealed that the superficial cells consisted of 35 % insulin-secreting B-cells and 65 % non-B-cells (A- and D-cells). 2. Two types of cell, with distinct electrophysiological properties, could be functionally identified. One of these generated oscillatory electrical activity when the islet was expose...

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Publication status:
Published

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Authors


Galvanovskis, J More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Journal:
The Journal of physiology
Volume:
521 Pt 3
Issue:
3
Pages:
717-728
Publication date:
1999-12-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:780c3cd5-70b1-4b84-9c09-c54ff57e6149
Source identifiers:
25710
Local pid:
pubs:25710

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