Omni-supervised domain adversarial training for white matter hyperintensity segmentation in the UK Biobank

Conference item

White matter hyperintensities (WMHs, or lesions) appear as hyperintense, localized regions on T2-weighted and FLAIR brain MR images. The heterogeneity in lesion characteristics due to subject-level (e.g., local intensity/contrast) and population-level (e.g., demographic, scanner-related) variations make their segmentation highly challenging. Here, we propose a framework for adapting a state-of-the-art WMH segmentation method with high accuracy from a small, labeled source data (MICCAI WMH segmentation challenge 2017 training data) to a larger dataset such as the UK Biobank without the need of additional manual training labels, using domain adversarial training with omni-supervised learning. Given the well-known association of WMHs with age, the proposed method uses a multi-tasking model for learning lesion segmentation, domain adaptation and age prediction simultaneously. On a subset of the UK Biobank dataset, the proposed method achieves a lesion-level recall, lesion-level F1-measure and Dice overlap value of 0.95, 0.65 and 0.84 respectively, when compared to values of 0.75, 0.49 and 0.80 obtained from the pretrained state-of-the-art baseline method. The code for the method is available at https://github.com/v-sundaresan/omnisup_agepred_semidann.

Authors: Sundaresan, V; Dinsdale, NK; Jenkinson, M; Griffanti, L

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: IEEE
• Host title: Proceedings of the 19th International Symposium on Biomedical Imaging (ISBI 2022)
• Pages: 1-4
• Publication date: 2022-04-26
• Event title: 19th International Symposium on Biomedical Imaging (ISBI 2022)
• Event location: Kolkata, India
• Event website: https://biomedicalimaging.org/2022/
• Event start date: 2022-03-28
• Event end date: 2022-03-31
• DOI: 10.1109/ISBI52829.2022.9761539
• EISSN: 1945-8452
• ISSN: 1945-7928
• EISBN: 978-1-6654-2923-8
• ISBN: 978-1-6654-2924-5
• Language: English
• Keywords: FFR