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T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component.

Abstract:

Stimulation of the T cell antigen receptor (TCR) induces formation of a phosphorylation-dependent signaling network via multiprotein complexes, whose compositions and dynamics are incompletely understood. Using stable isotope labeling by amino acids in cell culture (SILAC)-based quantitative proteomics, we investigated the kinetics of signal propagation after TCR-induced protein tyrosine phosphorylation. We confidently assigned 77 proteins (of 758 identified) as a direct or indirect consequen...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m110.201236

Authors


Brockmeyer, C More by this author
Trudgian, DC More by this author
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Journal:
The Journal of biological chemistry
Volume:
286
Issue:
9
Pages:
7535-7547
Publication date:
2011-03-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:77f925cb-449f-436e-b528-537d797fd59a
Source identifiers:
110186
Local pid:
pubs:110186

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