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The filling of granules into hard gelatine capsules.

Abstract:

Four different granule size fractions of Sorbitol instant(R) were filled into hard gelatine capsules on a tamp filling (Bosch) and a dosator nozzle machine (Zanasi) to allow comparison of the filling principles. An acceptable filling performance was always achieved and was independent of the machine type employed. Tamp filling was found to be slightly better for the coarser granule size fractions, because it does not seem to rely on a firm plug formation. A direct relationship between the ang...

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Publication status:
Published

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Authors


Podczeck, F More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Newton, JM More by this author
Publisher:
Elsevier
Journal:
International journal of pharmaceutics
Volume:
188
Issue:
1
Pages:
59-69
Publication date:
1999-10-05
DOI:
EISSN:
1873-3476
ISSN:
0378-5173
URN:
uuid:77eaa4c8-3194-4fbc-89ca-8c924b25cd99
Source identifiers:
176929
Local pid:
pubs:176929

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