- Abstract:
-
In observational studies, type 2 diabetes is associated with 2- to 4-fold higher risks of cardiovascular diseases (CVD). Using data from the China Kadoorie Biobank, we examined associations of genetically-predicted type 2 diabetes with CVD among ∼160,000 participants, to assess whether these relationships are causal. A type 2 diabetes genetic risk score (comprising 48 established risk variants) was associated with the presence of carotid plaque (OR 1.17 [95% CI...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer Reviewed
- Version:
- Accepted Manuscript
- Files:
-
-
(pdf, 868.3KB)
-
- Publisher copy:
- 10.2337/db19-0224
-
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- Publisher:
- American Diabetes Association Publisher's website
- Journal:
- Diabetes Journal website
- Volume:
- 68
- Issue:
- 11
- Pages:
- 2155-2164
- Publication date:
- 2019-08-09
- Acceptance date:
- 2019-08-05
- DOI:
- EISSN:
-
1939-327X
- ISSN:
-
0012-1797
- Pubs id:
-
pubs:1041812
- URN:
-
uri:77e3d098-2a9f-4fe9-8252-1707983769c7
- UUID:
-
uuid:77e3d098-2a9f-4fe9-8252-1707983769c7
- Local pid:
- pubs:1041812
- Language:
- English
- Keywords:
- Copyright holder:
- American Diabetes Association
- Copyright date:
- 2019
- Notes:
- © American Diabetes Association 2019. This is the accepted manuscript version of the article. The final version is available online from American Diabetes Association at: https://doi.org/10.2337/db19-0224
Journal article
Genetic predisposition to type 2 diabetes and risk of subclinical atherosclerosis and cardiovascular diseases among 160,000 Chinese adults
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