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Genetic predisposition to type 2 diabetes and risk of subclinical atherosclerosis and cardiovascular diseases among 160,000 Chinese adults

Abstract:

In observational studies, type 2 diabetes is associated with 2- to 4-fold higher risks of cardiovascular diseases (CVD). Using data from the China Kadoorie Biobank, we examined associations of genetically-predicted type 2 diabetes with CVD among ∼160,000 participants, to assess whether these relationships are causal. A type 2 diabetes genetic risk score (comprising 48 established risk variants) was associated with the presence of carotid plaque (OR 1.17 [95% CI...

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Publication status:
Published
Peer review status:
Peer Reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.2337/db19-0224

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Subgroup:
Clinical Trial Service Unit
Oxford college:
St Annes College
Role:
Author
ORCID:
0000-0002-9181-6886
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Publisher:
American Diabetes Association Publisher's website
Journal:
Diabetes Journal website
Volume:
68
Issue:
11
Pages:
2155-2164
Publication date:
2019-08-09
Acceptance date:
2019-08-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
Pubs id:
pubs:1041812
URN:
uri:77e3d098-2a9f-4fe9-8252-1707983769c7
UUID:
uuid:77e3d098-2a9f-4fe9-8252-1707983769c7
Local pid:
pubs:1041812
Language:
English
Keywords:

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