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TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines.

Abstract:

OBJECTIVES: To investigate the expression and function of triggering receptor expressed on myeloid cells-1 (TREM-1) in the synovium of human RA patients as well as the level of soluble TREM-1 in the plasma of RA patients. METHODS: Twenty-four RA synovial samples were analysed by gene expression oligonucleotide microarrays. Expression levels of TREM-1 mRNA in murine CIA paws were determined by quantitative PCR (qPCR). TREM-1 protein expression was detected by immunohistochemistry in five RA s...

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Publication status:
Published

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Publisher copy:
10.1093/rheumatology/kep235

Authors


Gregory, B More by this author
Pittman, DD More by this author
Feldman, JL More by this author
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Journal:
Rheumatology (Oxford, England)
Volume:
48
Issue:
11
Pages:
1352-1358
Publication date:
2009-11-05
DOI:
EISSN:
1462-0332
ISSN:
1462-0324
URN:
uuid:779d1245-eb3a-429b-860b-0508bda70438
Source identifiers:
224386
Local pid:
pubs:224386

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