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Quantitative Comparison of Effects of Dofetilide, Sotalol, Quinidine, and Verapamil between Human Ex vivo Trabeculae and In silico Ventricular Models Incorporating Inter-Individual Action Potential Variability

Abstract:

Background: In silico modeling could soon become a mainstream method of pro-arrhythmic risk assessment in drug development. However, a lack of human-specific data and appropriate modeling techniques has previously prevented quantitative comparison of drug effects between in silico models and recordings from human cardiac preparations. Here, we directly compare changes in repolarization biomarkers caused by dofetilide, dl-sotalol, quinidine, and verapamil, between in silico populations of huma...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3389/fphys.2017.00597

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Computer Science
Abi-Gerges, N More by this author
Miller, PE More by this author
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Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Physiology Journal website
Volume:
8
Pages:
597
Publication date:
2017-08-18
Acceptance date:
2017-08-02
DOI:
EISSN:
1664-042X
Pubs id:
pubs:724840
URN:
uri:778fc76f-d7b4-4575-a073-ce3230d7ae3c
UUID:
uuid:778fc76f-d7b4-4575-a073-ce3230d7ae3c
Local pid:
pubs:724840

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