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Journal article

Lex2B, a phase-variable glycosyltransferase, adds either a glucose or a galactose to Haemophilus influenzae lipopolysaccharide.

Abstract:

Nontypeable Haemophilus influenzae is a commensal that frequently causes otitis media and respiratory tract infections. The lex2 locus encodes a glycosyltransferase that is phase variably expressed and contributes to the significant intrastrain heterogeneity of lipopolysaccharide (LPS) composition in H. influenzae. In serotype b strains, Lex2B adds the second beta-glucose in the oligosaccharide extension from the proximal heptose of the triheptose inner core backbone; this extension includes ...

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Publication status:
Published

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Publisher copy:
10.1128/iai.01446-08

Authors


Deadman, ME More by this author
Hermant, P More by this author
Engskog, M More by this author
Makepeace, K More by this author
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Journal:
Infection and immunity
Volume:
77
Issue:
6
Pages:
2376-2384
Publication date:
2009-06-05
DOI:
EISSN:
1098-5522
ISSN:
0019-9567
URN:
uuid:778b9e63-13fa-4759-a23e-a06fea2814ad
Source identifiers:
115639
Local pid:
pubs:115639

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