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Comparative assessment of vaccine vectors encoding ten malaria antigens identifies two protective liver-stage candidates.

Abstract:

The development of an efficacious Plasmodium falciparum malaria vaccine remains a top priority for global health. Vaccination with irradiated sporozoites is able to provide complete sterile protection through the action of CD8(+) T cells at the liver-stage of infection. However, this method is currently unsuitable for large-scale deployment and focus has instead turned to the development of sub-unit vaccines. Sub-unit vaccine efforts have traditionally focused on two well-known pre-erythrocyt...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Published version

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Publisher copy:
10.1038/srep11820

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Jenner Institute
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Jenner Institute
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Jenner Institute
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Jenner Institute
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Funding agency for:
Salman, AM
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Funding agency for:
Spencer, AJ
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Funding agency for:
Hill, AV
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific reports Journal website
Volume:
5
Pages:
11820
Publication date:
2015-07-05
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
URN:
uuid:777ef3c6-29c9-4635-835c-44fb68ae2c28
Source identifiers:
531457
Local pid:
pubs:531457
Language:
English

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