Journal article icon

Journal article

Microglia colonize the developing brain by clonal expansion of highly proliferative progenitors, following allometric scaling

Abstract:

Microglia arise from the yolk sac and enter the brain during early embryogenesis. Upon entry, microglia undergo in situ proliferation and eventually colonize the entire brain by the third postnatal week in mice. However, the intricacies of their developmental expansion remain unclear. Here, we characterize the proliferative dynamics of microglia during embryonic and postnatal development using complementary fate-mapping techniques. We demonstrate that the developmental c...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1016/j.celrep.2023.112425

Authors


Publisher:
Cell Press
Journal:
Cell Reports More from this journal
Volume:
42
Issue:
5
Article number:
112425
Publication date:
2023-04-25
Acceptance date:
2023-04-06
DOI:
ISSN:
2211-1247
Language:
English
Keywords:
Pubs id:
1339135
Local pid:
pubs:1339135
Deposit date:
2023-04-27

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP