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CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression

Abstract:

CD147 is a broadly expressed plasma membrane glycoprotein containing two immunoglobulin-like domains and a single charge-containing transmembrane domain. Here we use co-immunoprecipitation and chemical cross-linking to demonstrate that CD147 specifically interacts with MCT1 and MCT4, two members of the proton-linked monocarboxylate (lactate) transporter family that play a fundamental role in metabolism, but not with MCT2. Studies with a CD2-CD147 chimera implicate the transmembrane and cytopl...

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Authors


Wilson, MC More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Journal:
EMBO Journal
Volume:
19
Issue:
15
Pages:
3896-3904
Publication date:
2000-08-01
ISSN:
0261-4189
URN:
uuid:7772d6b8-fafa-4d8e-a901-e03ec26ac36e
Source identifiers:
171874
Local pid:
pubs:171874

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