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Proximity extension assay testing reveals novel diagnostic biomarkers of atypical parkinsonian syndromes

Abstract:

Objective The high degree of clinical overlap between atypical parkinsonian syndromes (APS) and Parkinson’s disease (PD) makes diagnosis challenging. We aimed to identify novel diagnostic protein biomarkers of APS using multiplex proximity extension assay (PEA) testing.

Methods Cerebrospinal fluid (CSF) samples from two independent cohorts, each consisting of APS and PD cases, and controls, were analysed for neurofilament light chain (NF-L) and Olin...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1136/jnnp-2018-320151

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Publisher:
BMJ Publishing Group
Journal:
Journal of Neurology, Neurosurgery and Psychiatry More from this journal
Volume:
90
Issue:
7
Pages:
768-773
Publication date:
2019-03-13
Acceptance date:
2019-02-11
DOI:
EISSN:
1468-330X
ISSN:
0022-3050
Pmid:
30867224
Language:
English
Keywords:
Pubs id:
pubs:984096
UUID:
uuid:776b88fd-1b9e-49f2-ade3-3777bea7fc5e
Local pid:
pubs:984096
Source identifiers:
984096
Deposit date:
2019-03-23

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