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Proximity extension assay testing reveals novel diagnostic biomarkers of atypical parkinsonian syndromes

Abstract:

Objective The high degree of clinical overlap between atypical parkinsonian syndromes (APS) and Parkinson’s disease (PD) makes diagnosis challenging. We aimed to identify novel diagnostic protein biomarkers of APS using multiplex proximity extension assay (PEA) testing.

Methods Cerebrospinal fluid (CSF) samples from two independent cohorts, each consisting of APS and PD cases, and controls, were analysed for neurofilament light chain (NF-L) and Olin...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1136/jnnp-2018-320151

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ORCID:
0000-0001-6844-882X
Woodside, J More by this author
Magdalinou, NK More by this author
Chelban, V More by this author
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Publisher:
BMJ Publishing Group Publisher's website
Journal:
Journal of Neurology, Neurosurgery and Psychiatry Journal website
Volume:
90
Issue:
7
Pages:
768-773
Publication date:
2019-03-13
Acceptance date:
2019-02-11
DOI:
EISSN:
1468-330X
ISSN:
0022-3050
Pubs id:
pubs:984096
URN:
uri:776b88fd-1b9e-49f2-ade3-3777bea7fc5e
UUID:
uuid:776b88fd-1b9e-49f2-ade3-3777bea7fc5e
Local pid:
pubs:984096

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