The time course and chromosomal localization of recombination-related proteins at meiosis in the mouse are compatible with models that can resolve the early DNA-DNA interactions without reciprocal recombination.

Journal article

During mouse meiosis, the early prophase RAD51/DMC1 recombination protein sites, which are associated with the chromosome cores and which serve as markers for ongoing DNA-DNA interactions, are in ten-fold excess of the eventual reciprocal recombinant events. Most, if not all, of these early interactions are eliminated as prophase progresses. The manner in which these sites are eliminated is the focus of this investigation. We report that these sites acquire replication protein A, RPA and the ...

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Authors: Moens, P; Kolas, N; Tarsounas, M; Marcon, E; Cohen, P

• Publication status: Published
• Journal: Journal of cell science
• Volume: 115
• Issue: Pt 8
• Pages: 1611-1622
• Publication date: 2002-04-01
• EISSN: 1477-9137
• ISSN: 0021-9533
• Language: English
• Keywords: Rad51 Recombinase; Animals; Adaptor Proteins, Signal Transducing; DNA Helicases; Mice; Chromosomal Proteins, Non-Histone; DNA-Binding Proteins; Meiosis; Time Factors; Saccharomyces cerevisiae Proteins; Microscopy, Immunoelectron; Nuclear Proteins; Chromosomes; Humans; RecQ Helicases; DNA; Male; Recombination, Genetic; Spermatocytes; Rats; Models, Genetic; Adenosine Triphosphatases; Fungal Proteins; Cell Nucleus