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The time course and chromosomal localization of recombination-related proteins at meiosis in the mouse are compatible with models that can resolve the early DNA-DNA interactions without reciprocal recombination.

Abstract:

During mouse meiosis, the early prophase RAD51/DMC1 recombination protein sites, which are associated with the chromosome cores and which serve as markers for ongoing DNA-DNA interactions, are in ten-fold excess of the eventual reciprocal recombinant events. Most, if not all, of these early interactions are eliminated as prophase progresses. The manner in which these sites are eliminated is the focus of this investigation. We report that these sites acquire replication protein A, RPA and the ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
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Journal:
Journal of cell science
Volume:
115
Issue:
Pt 8
Pages:
1611-1622
Publication date:
2002-04-05
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:7769f453-a3d8-4713-b025-5366ec6f98de
Source identifiers:
131334
Local pid:
pubs:131334

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