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Neural plasticity in human brain connectivity: the effects of long term deep brain stimulation of the subthalamic nucleus in Parkinson's disease.

Abstract:

BACKGROUND: Positive clinical outcomes are now well established for deep brain stimulation, but little is known about the effects of long-term deep brain stimulation on brain structural and functional connectivity. Here, we used the rare opportunity to acquire pre- and postoperative diffusion tensor imaging in a patient undergoing deep brain stimulation in bilateral subthalamic nuclei for Parkinson's Disease. This allowed us to analyse the differences in structural connectivity before and aft...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Role:
Author
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Journal:
PloS one
Volume:
9
Issue:
1
Pages:
e86496
Publication date:
2014-01-22
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:776517bc-ffa0-462a-b7cd-a7a694a59603
Source identifiers:
446958
Local pid:
pubs:446958

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