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Journal article

Rapid identification of novel functional promoters for gene therapy

Abstract:

Transcriptional control of transgene expression is crucial to successful gene therapy, yet few promoter/enhancer combinations have been tested in clinical trials. We created a simple, desktop computer database and populated it with promoter sequences from publicly available sources. From this database, we rapidly identified novel CpG-free promoter sequences suitable for use in non-inflammatory, non-viral in vivo gene transfer. In a simple model of lung gene transfer, five of the six promoter ...

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Publisher copy:
10.1007/s00109-012-0928-6

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Journal:
Journal of Molecular Medicine
Volume:
90
Issue:
12
Pages:
1487-1496
Publication date:
2012-12-05
DOI:
EISSN:
1432-1440
ISSN:
0946-2716
URN:
uuid:775f750e-c4cc-45f4-9af5-533f5eb86e6e
Source identifiers:
429554
Local pid:
pubs:429554
Language:
English
Keywords:

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