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Journal article

Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma.

Abstract:

Angiogenesis is not only dependent on endothelial cell invasion and proliferation, it also requires pericyte coverage of vascular sprouts for stabilization of vascular walls. Clinical efficacy of angiogenesis inhibitors targeting the vascular endothelial growth factor (VEGF) signaling pathway is still limited to date. We hypothesized that the level of vessel maturation is critically involved in the response to antiangiogenic therapies. To test this hypothesis, we evaluated the vascular networ...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20091846

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Journal:
The Journal of experimental medicine
Volume:
207
Issue:
3
Pages:
491-503
Publication date:
2010-03-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:7754e61b-0dfc-4ba2-b1ee-277e0547186a
Source identifiers:
119504
Local pid:
pubs:119504

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