Journal article
A GCH1 haplotype confers sex-specific susceptibility to pain crises and altered endothelial function in adults with sickle cell anemia.
- Abstract:
-
GTP cyclohydrolase (GCH1) is rate limiting for tetrahydrobiopterin (BH4) synthesis, where BH4 is a cofactor for nitric oxide (NO) synthases and aromatic hydroxylases. GCH1 polymorphisms are implicated in the pathophysiology of pain, but have not been investigated in African populations. We examined GCH1 and pain in sickle cell anemia where GCH1 rs8007267 was a risk factor for pain crises in discovery (n = 228; odds ratio [OR] 2.26; P = 0.009) and replication (n = 513; OR 2.23; P = 0.004) coho...
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- Publication status:
- Published
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- Publisher copy:
- 10.1002/ajh.23613
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Authors
Bibliographic Details
- Journal:
- American journal of hematology
- Volume:
- 89
- Issue:
- 2
- Pages:
- 187-193
- Publication date:
- 2014-02-05
- DOI:
- EISSN:
-
1096-8652
- ISSN:
-
0361-8609
- URN:
-
uuid:77541561-2bd9-46f0-8abc-f2c11fa1491e
- Source identifiers:
-
434365
- Local pid:
- pubs:434365
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 2014
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