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Docosahexaenoic acid, a constituent of rodent fetal serum and fish oil diets, inhibits acquisition of macrophage tumoricidal function.

Abstract:

Macrophage (M phi) activation is deficient in the fetus and neonate, at times when the serum concentration of docosahexaenoic acid (DHA; 22:6n3) is approximately 10-fold higher than in the adult. We tested the effects of highly purified DHA on M phi activation in vitro. M phi were stimulated with rIFN-gamma plus either of two second or "triggering" signals, LPS or heat-killed Listeria monocytogenes. M phi activation was assayed as the lysis of P815 mastocytoma cells, which are resistant to TN...

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
144
Issue:
12
Pages:
4888-4897
Publication date:
1990-06-29
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:774cef10-fa2f-4c64-963a-f20a3c1037de
Source identifiers:
483514
Local pid:
pubs:483514

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