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Mouse embryonic phenotyping by morphometric analysis of MR images.

Abstract:

A new method is described for automatic detection of subtle morphological phenotypes in mouse embryos. Based on high-resolution magnetic resonance imaging scanning and nonlinear image alignment, this method is demonstrated by comparing the morphology of two inbred strains, C57BL/6J and 129Sv/S1ImJ, at 15.5 days postconception. Mouse embryo morphology was found to be highly amenable to this kind of analysis with very low levels (on average 110 μm) of residual anatomical variation within strain...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Role:
Author
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Journal:
Physiological genomics
Volume:
42A
Issue:
2
Pages:
89-95
Publication date:
2010-10-05
DOI:
EISSN:
1531-2267
ISSN:
1094-8341
URN:
uuid:774c6e9c-29ee-44f0-bfbb-12c938e3395b
Source identifiers:
105953
Local pid:
pubs:105953

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