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Journal article

Base excision repair processing of abasic site/single-strand break lesions within clustered damage sites associated with XRCC1 deficiency.

Abstract:

Ionizing radiation induces clustered DNA damage, which presents a challenge to the cellular repair machinery. The repair efficiency of a single-strand break (SSB) is approximately 4x less than that for repair of an abasic (AP) site when in a bistranded cluster containing 8-oxoG. To explore whether this difference in repair efficiency involves XRCC1 or other BER proteins, synthetic oligonucleotides containing either an AP site or HAP1-induced SSB (HAP1-SSB) 1 or 5 bp 5' or 3' to 8-oxoG on the ...

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Publication status:
Published

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Publisher copy:
10.1093/nar/gkm947

Authors


Mourgues, S More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Journal:
Nucleic acids research
Volume:
35
Issue:
22
Pages:
7676-7687
Publication date:
2007
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:774a19c9-2f0f-4c9a-9ac5-34301de6a23f
Source identifiers:
130883
Local pid:
pubs:130883

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