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The kinetoplastid kinetochore protein KKT4 is an unconventional microtubule tip–coupling protein

Abstract:

Kinetochores are multiprotein machines that drive chromosome segregation by maintaining persistent, load-bearing linkages between chromosomes and dynamic microtubule tips. Kinetochores in commonly studied eukaryotes bind microtubules through widely conserved components like the Ndc80 complex. However, in evolutionarily divergent kinetoplastid species such as Trypanosoma brucei, which causes sleeping sickness, the kinetochores assemble from a unique set of proteins lacking homology to any know...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1083/jcb.201711181

Authors


Llauró, A More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Bailey, ME More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
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Funding agency for:
Akiyoshi, B
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Funding agency for:
Akiyoshi, B
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Funding agency for:
Akiyoshi, B
Publisher:
Rockefeller University Press Publisher's website
Journal:
Journal of Cell Biology Journal website
Volume:
217
Issue:
11
Pages:
3886-3900
Publication date:
2018-09-12
Acceptance date:
2018-08-24
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
Pubs id:
pubs:910006
URN:
uri:76f8a5bc-5458-410d-9028-420893ea9fef
UUID:
uuid:76f8a5bc-5458-410d-9028-420893ea9fef
Local pid:
pubs:910006

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