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Neuroendocrine and temperature effects of nefazodone in healthy volunteers.

Abstract:

The effects of a novel antidepressant, nefazodone (50 mg, 100 mg, and 200 mg orally) on neuroendocrine function and temperature were assessed using a single-blind, crossover design in eight healthy male volunteers. Nefazodone significantly increased plasma levels of prolactin (PRL) and raised oral temperature. There was also a trend towards an increase in plasma cortisol. These results are consistent with an acute facilitatory effect of some aspects of 5-HT neurotransmission, perhaps mediated...

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Publication status:
Published

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Authors


Hockney, RA More by this author
Campling, G More by this author
Journal:
Biological psychiatry
Volume:
33
Issue:
2
Pages:
115-119
Publication date:
1993-01-05
DOI:
EISSN:
1873-2402
ISSN:
0006-3223
URN:
uuid:76f4e336-18c5-4da0-a357-0aa83e83fcab
Source identifiers:
186027
Local pid:
pubs:186027

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