Subcellular localisation of cyclin B, Cdc2 and p21(WAF1/CIP1) in breast cancer. association with prognosis.

Journal article

The heterodimeric cyclin B/Cdc2 protein kinase governs entry into mitosis, and can be negatively regulated through p53-mediated transcriptional induction of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1). Ectopic expression of p21(WAF1/CIP1) in cultured cells has been shown previously to influence the subcellular distribution of the cyclin-dependent kinases (CDKs) including Cdc2. In this study, we have examined the subcellular localisation of Cdc2, cyclin B and p21(WAF1/CIP1) by immunoh...

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Authors: Winters, Z; Hunt, N; Bradburn, M; Royds, J; Turley, H

• Publication status: Published
• Journal: European journal of cancer (Oxford, England : 1990)
• Volume: 37
• Issue: 18
• Pages: 2405-2412
• Publication date: 2001-12-01
• DOI: 10.1016/s0959-8049(01)00327-6
• EISSN: 1879-0852
• ISSN: 0959-8049
• Language: English
• Keywords: Carcinoma, Ductal, Breast; Multivariate Analysis; Neoplasm Recurrence, Local; Aged; Tumor Suppressor Protein p53; Disease-Free Survival; Cyclin-Dependent Kinase Inhibitor p21; Immunohistochemistry; Lymphatic Metastasis; Predictive Value of Tests; Middle Aged; Cyclins; Cyclin B; CDC2 Protein Kinase; Humans; Adult; Aged, 80 and over; Neoplasm Proteins; Breast Neoplasms