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Subcellular localisation of cyclin B, Cdc2 and p21(WAF1/CIP1) in breast cancer. association with prognosis.

Abstract:

The heterodimeric cyclin B/Cdc2 protein kinase governs entry into mitosis, and can be negatively regulated through p53-mediated transcriptional induction of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1). Ectopic expression of p21(WAF1/CIP1) in cultured cells has been shown previously to influence the subcellular distribution of the cyclin-dependent kinases (CDKs) including Cdc2. In this study, we have examined the subcellular localisation of Cdc2, cyclin B and p21(WAF1/CIP1) by immunoh...

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Publication status:
Published

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Journal:
European journal of cancer (Oxford, England : 1990)
Volume:
37
Issue:
18
Pages:
2405-2412
Publication date:
2001-12-05
DOI:
EISSN:
1879-0852
ISSN:
0959-8049
URN:
uuid:76f357df-3b71-4c98-a131-6c9f5a9d8e1e
Source identifiers:
29870
Local pid:
pubs:29870

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