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The effect of tetracyclines on quantitative measures of osteoclast morphology.

Abstract:

We report the effects of the tetracycline analogues 4-dedimethylaminotetracycline (CMT-1) and minocycline on osteoclast spreading and motility. Both agents influenced the morphometric descriptor of cell spread area, rho, producing cellular retraction or an R effect (half-times: 30 and 44 minutes for CMT-1 and minocycline, respectively). At the concentrations employed, the tetracycline-induced R effects were significantly slower than, but were qualitatively similar to, those resulting from Ca2...

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Publisher copy:
10.1007/bf01149962

Authors


Moonga, BS More by this author
Towhidul Alam, AS More by this author
Shankar, VS More by this author
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Publisher:
Kluwer Academic Publishers-Plenum Publishers
Journal:
Bioscience reports
Volume:
13
Issue:
3
Pages:
175-182
Publication date:
1993-06-05
DOI:
EISSN:
1573-4935
ISSN:
0144-8463
URN:
uuid:76ef2852-a710-4bc3-9d72-933f9aef7390
Source identifiers:
475702
Local pid:
pubs:475702

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