- Abstract:
-
The first transmembrane (TM1) helix in the red cell anion exchanger (AE1, Band 3, SLC4A1) acts as an internal signal anchor that binds the signal recognition particle and directs the nascent polypeptide chain to the endoplasmic reticulum (ER) membrane where it moves from the translocon laterally into the lipid bilayer. The sequence N-terminal to TM1 forms an amphipathic helix that lies at the membrane interface connected to TM1 by a bend at Pro403. Southeast Asian Ovalocytosis (SAO) is a red ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 3.0MB)
-
- Publisher copy:
- 10.1021/acs.biochem.6b00966
-
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- Publisher:
- American Chemical Society Publisher's website
- Journal:
- Biochemistry Journal website
- Volume:
- 56
- Issue:
- 5
- Pages:
- 712-722
- Publication date:
- 2017-01-09
- Acceptance date:
- 2017-01-09
- DOI:
- EISSN:
-
1520-4995
- ISSN:
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0006-2960
- Pubs id:
-
pubs:668997
- URN:
-
uri:76eed5ef-c165-484c-ab42-51cb1bdb6917
- UUID:
-
uuid:76eed5ef-c165-484c-ab42-51cb1bdb6917
- Local pid:
- pubs:668997
- Copyright holder:
- Copyright 2017 © American Chemical Society
- Copyright date:
- 2017
- Notes:
- ACS AuthorChoice - This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Journal article
Effect of the Southeast Asian ovalocytosis deletion on the conformational dynamics of the signal- anchor transmembrane segment 1 of the red cell anion exchanger 1 (AE1, Band 3, SLC4A1)
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