Journal article icon

Journal article

Effect of the Southeast Asian ovalocytosis deletion on the conformational dynamics of the signal- anchor transmembrane segment 1 of the red cell anion exchanger 1 (AE1, Band 3, SLC4A1)

Abstract:

The first transmembrane (TM1) helix in the red cell anion exchanger (AE1, Band 3, SLC4A1) acts as an internal signal anchor that binds the signal recognition particle and directs the nascent polypeptide chain to the endoplasmic reticulum (ER) membrane where it moves from the translocon laterally into the lipid bilayer. The sequence N-terminal to TM1 forms an amphipathic helix that lies at the membrane interface connected to TM1 by a bend at Pro403. Southeast Asian Ovalocytosis (SAO) is a red ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1021/acs.biochem.6b00966

Authors


More by this author
Department:
Oxford, MSD, NDM Experimental Medicine
Role:
Author
More by this author
Department:
Oxford, MSD, NDM Experimental Medicine
Role:
Author
More from this funder
Funding agency for:
Fowler, P
More from this funder
Funding agency for:
Sansom, M
Publisher:
American Chemical Society Publisher's website
Journal:
Biochemistry Journal website
Volume:
56
Issue:
5
Pages:
712-722
Publication date:
2017-01-09
Acceptance date:
2017-01-09
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
Pubs id:
pubs:668997
URN:
uri:76eed5ef-c165-484c-ab42-51cb1bdb6917
UUID:
uuid:76eed5ef-c165-484c-ab42-51cb1bdb6917
Local pid:
pubs:668997

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP