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Sensorimotor adaptation as a behavioural biomarker of early spinocerebellar ataxia type 6

Abstract:

Early detection of the behavioural deficits of neurodegenerative diseases may help to describe the pathogenesis of such diseases and establish important biomarkers of disease progression. The aim of this study was to identify how sensorimotor adaptation of the upper limb, a cerebellar-dependent process restoring movement accuracy after introduction of a perturbation, is affected at the pre-clinical and clinical stages of spinocerebellar ataxia type 6 (SCA6), an inherited neurodegenerative dis...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41598-017-02469-7

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy & Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
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Funding agency for:
Benitez-Riveiro, S
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Funding agency for:
Nemeth, AH
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Funding agency for:
Nemeth, AH
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Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Pages:
2366
Publication date:
2017-05-24
Acceptance date:
2017-04-11
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Pubs id:
pubs:697364
URN:
uri:76e22055-7289-402d-a3be-96d25dc3f084
UUID:
uuid:76e22055-7289-402d-a3be-96d25dc3f084
Local pid:
pubs:697364

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