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Immunodominance of cytotoxic T lymphocyte epitopes co-injected in vivo and modulation by interleukin-12.

Abstract:

Immunodominance (ID) of T cell epitopes is a well-documented phenomenon that might have profound significance in the evolution of T cell responses to pathogens, tumors, autoantigens and vaccines. With the intention of developing vaccines composed of several cytotoxic T cell (CTL) epitopes, we injected mice with peptide mixtures containing two to five CTL epitopes and observed clear patterns of ID. In a first case, ID strictly correlated with the competitor activity of the individual peptides ...

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Publication status:
Published

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Publisher copy:
10.1002/eji.1830261124

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP
Brunda, MJ More by this author
Valmori, D More by this author
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Journal:
European journal of immunology
Volume:
26
Issue:
11
Pages:
2709-2716
Publication date:
1996-11-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:76e1ecc3-4a4c-4184-82a5-c0747dc638fd
Source identifiers:
20148
Local pid:
pubs:20148

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