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Identification of a di-leucine motif within the C terminus domain of the Menkes disease protein that mediates endocytosis from the plasma membrane.

Abstract:

The protein encoded by the Menkes disease gene (MNK) is localised to the Golgi apparatus and cycles between the trans-Golgi network and the plasma membrane in cultured cells on addition and removal of copper to the growth medium. This suggests that MNK protein contains active signals that are involved in the retention of the protein to the trans-Golgi network and retrieval of the protein from the plasma membrane. Previous studies have identified a signal involved in Golgi retention within tra...

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Publication status:
Published

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Journal:
Journal of cell science
Volume:
112 ( Pt 11)
Issue:
11
Pages:
1721-1732
Publication date:
1999-06-05
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:76ddb480-0d4e-4d69-bfba-0731e07d6404
Source identifiers:
31479
Local pid:
pubs:31479

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