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Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway.

Abstract:

(3R,5R)-Clavulanic acid (CA) is a clinically important inhibitor of Class A beta-lactamases. Sequence comparisons suggest that orf14 of the clavulanic acid biosynthesis gene cluster encodes for an acetyl transferase (CBG). Crystallographic studies reveal CBG to be a member of the emerging structural subfamily of tandem Gcn5-related acetyl transferase (GNAT) proteins. Two crystal forms (C2 and P2(1) space groups) of CBG were obtained; in both forms one molecule of acetyl-CoA (AcCoA) was bound ...

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Publication status:
Published

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Publisher copy:
10.1002/prot.22653

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Journal:
Proteins
Volume:
78
Issue:
6
Pages:
1398-1407
Publication date:
2010-05-05
DOI:
EISSN:
1097-0134
ISSN:
0887-3585
URN:
uuid:76db18db-4375-4e90-a91c-0e333d24f769
Source identifiers:
35020
Local pid:
pubs:35020

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