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HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRC01-class broadly neutralizing antibodies

Abstract:

Broadly neutralizing antibody (bnAb) induction is a high priority for effective HIV-1 vaccination. VRC01-class bnAbs that target the CD4 binding site (CD4bs) of trimeric HIV-1 envelope (Env) glycoprotein spikes are particularly attractive to elicit because of their extraordinary breadth and potency of neutralization in vitro and their ability to protect against infection in animal models. Glycans bordering the CD4bs impede the binding of germline-reverted forms of VRC01-class bnAbs and theref...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.ppat.1007431

Authors


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ORCID:
0000-0002-6653-6655
McGuire, AT More by this author
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ORCID:
0000-0002-4260-9784
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ORCID:
0000-0001-8676-2345
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Grant:
Collaboration for AIDS Vaccine Discovery, grant no. 1032144
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Grant:
Intramural Research Program of the Vaccine Research Center, NIAID
Center for HIV/AIDS Vaccine Immunology- Immunogen Design, U01 AI067854 to BFH
R01AI081625 to LS
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Pathogens Journal website
Volume:
14
Issue:
11
Pages:
Article: e1007431
Publication date:
2018-11-05
Acceptance date:
2018-10-24
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Pubs id:
pubs:940643
URN:
uri:76c6ef32-6f0d-48ae-b1eb-ca6e7bb4d91a
UUID:
uuid:76c6ef32-6f0d-48ae-b1eb-ca6e7bb4d91a
Local pid:
pubs:940643
Language:
English

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