Correlations of interictal FDG-PET metabolism and ictal SPECT perfusion changes in human temporal lobe epilepsy with hippocampal sclerosis.

Journal article

BACKGROUND: The pathophysiological role of the extensive interictal cerebral hypometabolism in complex partial seizures (CPS) in refractory mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE-HS) is poorly understood. Our aim was to study ictal-interictal SPECT perfusion versus interictal fluorodeoxyglucose (FDG)-PET metabolic patterns. METHODS: Eleven adults with refractory unilateral mTLE-HS, who were rendered seizure free after epilepsy surgery, were included. All had an interic...

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Authors: Nelissen, N; Van Paesschen, W; Baete, K; Van Laere, K; Palmini, A

• Journal: NeuroImage
• Volume: 32
• Issue: 2
• Pages: 684-695
• Publication date: 2006-08-01
• DOI: 10.1016/j.neuroimage.2006.04.185
• EISSN: 1095-9572
• ISSN: 1053-8119
• Language: English
• Keywords: Hippocampus; Organotechnetium Compounds; Temporal Lobe; Frontal Lobe; Tomography, Emission-Computed, Single-Photon; Statistics as Topic; Blood Glucose; Evoked Potentials; Adult; Middle Aged; Energy Metabolism; Algorithms; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Regional Blood Flow; Fluorodeoxyglucose F18; Sclerosis; Positron-Emission Tomography; Cysteine; Dominance, Cerebral; Cerebral Cortex; Cerebellum; Female; Male; Epilepsy, Temporal Lobe; Humans; Electroencephalography