Characterization of short tandem repeats from thirty-one human telomeres.

Journal article

Completion of genetic and physical maps requires markers from the ends (telomeres) of every human chromosome. We have searched for short tandem repeats (microsatellites) in cosmid and P1 clones and generated 661 sequence-tagged sites (STS) from the terminal 300 kb of 31 human chromosome ends. PCR assays were successfully designed for 58 microsatellites and mapped both genetically and on radiation hybrids (RHs) to confirm their telomeric location. Sequence analysis revealed marked variation in...

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Authors: Rosenberg, M; Hui, L; Ma, J; Nusbaum, H; Clark, K

• Publication status: Published
• Journal: Genome research
• Volume: 7
• Issue: 9
• Pages: 917-923
• Publication date: 1997-09-01
• EISSN: 1549-5469
• ISSN: 1088-9051
• Language: English
• Keywords: Base Sequence; Repetitive Sequences, Nucleic Acid; Telomere; Chromosomes, Human; Humans; Sequence Tagged Sites; Molecular Sequence Data; Chromosome Mapping; Sequence Analysis, DNA