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Bicaudal-D regulates fragile X mental retardation protein levels, motility, and function during neuronal morphogenesis.

Abstract:

The expression of the RNA-binding factor Fragile X mental retardation protein (FMRP) is disrupted in the most common inherited form of cognitive deficiency in humans. FMRP controls neuronal morphogenesis by mediating the translational regulation and localization of a large number of mRNA targets, and these functions are closely associated with transport of FMRP complexes within neurites by microtubule-based motors. However, the mechanisms that link FMRP to motors and regulate its transport ar...

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Publication status:
Published

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Publisher copy:
10.1016/j.cub.2010.07.016

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Current biology : CB
Volume:
20
Issue:
16
Pages:
1487-1492
Publication date:
2010-08-05
DOI:
EISSN:
1879-0445
ISSN:
0960-9822
URN:
uuid:76b9ba92-5ccc-49a6-84d7-8ba08bb69acd
Source identifiers:
66111
Local pid:
pubs:66111

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