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Membrane stiffness is modified by integral membrane proteins

Abstract:

The ease with which a cell membrane can bend and deform is important for a wide range of biological functions. Peripheral proteins that induce curvature in membranes (e.g. BAR domains) have been studied for a number of years. Little is known, however, about the effect of integral membrane proteins on the stiffness of a membrane (characterised by the bending rigidity, Kc). We demonstrate by computer simulation that adding integral membrane proteins at physiological densities alters the stiffne...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1039/C6SM01186A

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Department:
Oxford, MSD, Biochemistry
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Department:
Oxford, MSD, Biochemistry
Role:
Author
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Department:
Oxford, MSD, Biochemistry
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Author
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Alfred Benzon Foundation More from this funder
Biotechnology and Biological Sciences Research Council More from this funder
Publisher:
Royal Society of Chemistry Publisher's website
Journal:
Soft Matter Journal website
Volume:
12
Issue:
37
Pages:
7792-7803
Publication date:
2016-08-05
Acceptance date:
2016-08-25
DOI:
EISSN:
1744-6848
ISSN:
1744-683X
Pubs id:
pubs:646121
URN:
uri:76b714b5-04b6-4e07-aebc-75854f2b7613
UUID:
uuid:76b714b5-04b6-4e07-aebc-75854f2b7613
Local pid:
pubs:646121
Language:
English
Keywords:

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