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Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration.

Abstract:

FLT3-ITD-mediated leukemogenesis is associated with increased expression of oncogenic PIM serine/threonine kinases. To dissect their role in FLT3-ITD-mediated transformation, we performed bone marrow reconstitution assays. Unexpectedly, FLT3-ITD cells deficient for PIM1 failed to reconstitute lethally irradiated recipients, whereas lack of PIM2 induction did not interfere with FLT3-ITD-induced disease. PIM1-deficient bone marrow showed defects in homing and migration and displayed decreased s...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20082074

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Role:
Author
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Journal:
The Journal of experimental medicine
Volume:
206
Issue:
9
Pages:
1957-1970
Publication date:
2009-08-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:76a6dd16-4779-4996-b53c-4103514341cc
Source identifiers:
41331
Local pid:
pubs:41331

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