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Development of NIRS method for quality control of drug combination artesunate-azithromycin for the treatment of severe malaria

Abstract:

Near infrared spectroscopy (NIRS) methods were developed for the determination of analytical content of an antimalarial-antibiotic (artesunate and azithromycin) co-formulation in hard gelatin capsule (HGC). The NIRS consists of pre-processing treatment of spectra (raw spectra and first-derivation of two spectral zones), a unique principal component analysis model to ensure the specificity and then two partial least-squares regression models for the determination content of each active pharmac...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.jpba.2012.04.009

Authors


Gaubert, A More by this author
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Wellcome Trust More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Journal of Pharmaceutical and Biomedical Analysis Journal website
Volume:
67-68
Pages:
10-15
Publication date:
2012
DOI:
EISSN:
1873-264X
ISSN:
0731-7085
URN:
uuid:76a6c6f7-ed62-4ee5-afea-8b76af8c676e
Source identifiers:
340118
Local pid:
pubs:340118

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