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GFI1(36N) as a therapeutic and prognostic marker for myelodysplastic syndrome (MDS)

Abstract:

Inherited gene variants play an important role in malignant diseases. The transcriptional repressor Growth factor independence 1 (GFI1) regulates hematopoietic stem cell (HSC) self-renewal and differentiation. A single nucleotide polymorphism of GFI1 (rs34631763) generates a protein with an asparagine (N) instead of a serine (S) at position 36 (GFI1(36N)) and has a prevalence of 3-5% among Caucasians. Since GFI1 regulates myeloid development, we examined the role of GFI1(36N) on MDS disease c...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.exphem.2016.04.001

Authors


Botezatu, L More by this author
Michel, LC More by this author
Makishima, H More by this author
Schroeder, T More by this author
Germing, U More by this author
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Funding agency for:
Boultwood, J
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Funding agency for:
Pellagatti, A
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Funding agency for:
Khandanpour, C
Publisher:
Elsevier Publisher's website
Journal:
Experimental Hematology Journal website
Volume:
44
Issue:
7
Pages:
590–595.e1
Publication date:
2016-04-11
DOI:
EISSN:
1873-2399
ISSN:
0301-472X
URN:
uuid:76a3ea4a-341a-4882-a5c3-4a285320d97e
Source identifiers:
616818
Local pid:
pubs:616818
Paper number:
7
Language:
English

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