DNA double-strand break repair pathway choice in Dictyostelium.

Journal article

DNA double-strand breaks (DSBs) can be repaired by homologous recombination (HR) or non-homologous end joining (NHEJ). The mechanisms that govern whether a DSB is repaired by NHEJ or HR remain unclear. Here, we characterise DSB repair in the amoeba Dictyostelium. HR is the principal pathway responsible for resistance to DSBs during vegetative cell growth, a stage of the life cycle when cells are predominantly in G2. However, we illustrate that restriction-enzyme-mediated integration of DNA in...

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Authors: Hsu, D; Kiely, R; Couto, C; Wang, H; Hudson, J

• Publication status: Published
• Journal: Journal of cell science
• Volume: 124
• Issue: Pt 10
• Pages: 1655-1663
• Publication date: 2011-05-01
• DOI: 10.1242/jcs.081471
• EISSN: 1477-9137
• ISSN: 0021-9533
• Language: English
• Keywords: DNA Breaks, Double-Stranded; Transcription Factors; DNA, Protozoan; Recombination, Genetic; DNA Repair; DNA-Binding Proteins; DNA-Activated Protein Kinase; Dictyostelium; Antigens, Nuclear