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Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice.

Abstract:

OBJECTIVE: Increased production of reactive oxygen species and loss of endothelial nitric oxide (NO) bioactivity are key features of vascular disease states such as atherosclerosis. Tetrahydrobiopterin (BH4) is a required cofactor for NO synthesis by endothelial nitric oxide synthase (eNOS); pharmacologic studies suggest that reduced BH4 availability may be an important mediator of endothelial dysfunction in atherosclerosis. We aimed to investigate the importance of endothelial BH4 availabil...

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Publication status:
Published

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Authors


McAteer, MA More by this author
Choudhury, RP More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Journal:
Arteriosclerosis, thrombosis, and vascular biology
Volume:
24
Issue:
3
Pages:
445-450
Publication date:
2004-03-05
DOI:
EISSN:
1524-4636
ISSN:
1079-5642
URN:
uuid:769a0bc2-9e03-46ca-9510-a626abc39cf5
Source identifiers:
105214
Local pid:
pubs:105214

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