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Vaccine-mediated protection of pigs against infection with pandemic H1N1 2009 swine influenza A virus requires a close antigenic match between the vaccine antigen and challenge virus

Abstract:

Swine influenza A virus (SwIV) infection has considerable economic and animal welfare consequences and, because of the zoonotic potential, can also have public health implications. The 2009 pandemic H1N1 ‘swine-origin’ infection is now endemic in both pigs and humans. In Europe, avian-like H1avN1, human-like H1huN2, human-like swine H3N2 and, since 2009, pandemic H1N1 (pH1N1) lineage viruses and reassortants, constitute the dominant subtypes. In this study, we used a ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.vaccine.2019.02.078

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
Publisher:
Elsevier
Journal:
Vaccine More from this journal
Volume:
37
Issue:
17
Pages:
2288-2293
Publication date:
2019-03-23
Acceptance date:
2019-02-27
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
Pmid:
30914224
Language:
English
Keywords:
Pubs id:
pubs:986924
UUID:
uuid:7686a443-c0a9-4322-9256-fab0db5c966a
Local pid:
pubs:986924
Source identifiers:
986924
Deposit date:
2019-04-04

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