Journal article
Development of cancer metabolism as a therapeutic target: New pathways, patient studies, stratification and combination therapy
- Abstract:
- Cancer metabolism has undergone a resurgence in the last decade, 70 years after Warburg described aerobic glycolysis as a feature of cancer cells. A wide range of techniques have elucidated the complexity and heterogeneity in preclinical models and clinical studies. What emerges are the large differences between tissues, tumour types and intratumour heterogeneity. However, synergies with inhibition of metabolic pathways have been found for many drugs and therapeutic approaches, and a critical role of window studies and translational trial design is key to success.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 236.6KB, Terms of use)
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- Publisher copy:
- 10.1038/s41416-019-0666-4
Authors
- Publisher:
- Springer Nature
- Journal:
- British Journal of Cancer More from this journal
- Volume:
- 122
- Pages:
- 1-3
- Publication date:
- 2019-12-10
- Acceptance date:
- 2019-11-12
- DOI:
- EISSN:
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1532-1827
- ISSN:
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0007-0920
- Pmid:
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31819198
- Language:
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English
- Keywords:
- Pubs id:
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1078117
- Local pid:
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pubs:1078117
- Deposit date:
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2020-08-20
Terms of use
- Copyright holder:
- Adrian Harris
- Copyright date:
- 2020
- Rights statement:
- © The Author(s) 2019. Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
- Licence:
- CC Attribution (CC BY)
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